Efflux pump in bacteria
contribute to intrinsic resistance to a wide variety range of antibiotic andoften have a broad substrate range due to the lack of new antibacterial agents.
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Klebsiella pneumoniae |
There is considerable
interest in restoring the activities of older antibiotics by inhibiting the
action of efflux pump and there being a usual area of active drug development
by pharmaceutical companies, but the fact is that little is known about the
interaction of such inhibitors with the bacterium. The addition of
combinatorial drugs to the existing antibiotics can thereby enhance the
activity and restore its effective use in treatment regimens. Read more>>>>>>>>
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