Wednesday 21 June 2017

Formulation and Evaluation of Nystatin Vaginal Tablet

Nystatin was discovered in the New York State Health Laboratory is a antimycotic polyene antibiotic obtained from Streptomyces noursei. It is structurally similar toamphotericin B and has the same mechanism of action.

Nystatin Vaginal Tablet
Nystatin is 20-(4-amino-3,5-dihydroxy-6-methyl-oxan-2-yl)oxy-4,22,24,28,29,32,34,36-octahydroxy-2,3,5-trimethyl-26,38-dioxo-1-oxacyclooctatriaconta-6,8,12,14,16,18-hexaene-23-carboxylicacid.Its molecular formula is C47H75NO17. Nystatin is a yellow to light tan powder. It is freely soluble in dimethylformamide, slightly sparingly soluble in methyl alcohol, n-propyl alcohol and n-butyl alcohol, practically insoluble in alcohol, chloroform, and ether and insoluble in water.

No comments:

Post a Comment