Prodrug is a
substance which after administration is metabolized into a pharmacologically
active drug. Actually prodrug has least medicinal value in in-vitro/in-vivo
but after biotransformation by metabolism in invivo it releases
the active medicament.
A drug is a
substance which is a chemical entity, has definite structural skeleton,
obtained by natural or synthetic or semisynthetic source, which can fit on
bioreceptor platform having controlling capacity to control over the
biochemical malfunction.
Every drug is
xenobiotic because it is coming from outer source (xeno) and active in
biological unit (biotic). Prodrug is the precursor of drug which is made by
derivatization of the same to enhance the bioavailability by pharmacokinetics,
lipid solubility by partition coefficient and increase the physicochemical and
biochemical parameters by pharmacodynamics.
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