A new sulfonamide SAP (4-amino-N-(1, 5-dimethyl-3-
oxo-2-phenyl-2, 3-dihydro-1H-pyrazol-4-yl) benzene sulfonamide) 4 has been
synthesized by using Ampyrone with N-Acetylsulfanilyl chloride and
characterized by FT-IR, NMR, and LC-MS spectroscopy.
The inclusion complex of 4 with β-CD is achieved in the semi
aqueous medium by using Sonicator and is characterized with
the help of UV–Vis,
Fourier Transform Infrared spectrometer, Scanning Electron Microscope,
Differential Scanning Calorimetry, Thermo gravimetric Analyzer.
Finally, effect of in-vitro antimicrobial activity of the
inclusion complex has been studied with the free SAP. Successful conversion of the new
Sulfonamide to its inclusion complex with β-CD has been achieved by co
evaporation method.
